CAS:488832-69-5
488832-69-5
CAS号：488832-69-5
品名：伊利司莫elesclomol
中文别名：丙二酸-1,3-二[2-甲基-2-(苯基硫酮甲基)酰肼];
英文别名：STA-4783;1-N',3-N'-bis(benzenecarbonothioyl)-1-N',3-N'-dimethylpropanedihydrazide;Elesclomol;N-malonyl-bis(N'-thiobenzoyl-N'-methylhydrazide);
分子式：C19H20N4O2S2
分子量：400.518
精确质量：400.103
Psa：128.86
MDL号：MFCD12911784
密度：1.313
折射率：1.667
简介：Elesclomol(INN,codenamedSTA-4783)isadrugthattriggersapoptosis(programmedcelldeath)incancercells.ItisbeingdevelopedbySyntaPharmaceuticalsandGlaxoSmithKlineasachemotherapyadjuvant,andhasreceivedbothfasttrackandorphandrugstatusfromtheU.S.FoodandDrugAdministrationforthetreatmentofmetastaticmelanoma.SyntaPharmaceuticalsannouncedonFebruary26,2009thesuspensionofallclinicaltrialsinvolvingElesclomolduetosafetyconcerns.InMarch2010,SyntaannouncedthattheFDAhadapprovedresumingclinicaldevelopmentofelesclomol,andthattheyexpectedtoinitiateoneormoreclinicaltrialsforelesclomolinthesecondhalfoftheyear.
细胞骨架信号
