CAS:1195765-45-7
1195765-45-7
CAS号：1195765-45-7
品名：达帕菲尼dabrafenib
中文别名：达拉菲尼;
英文别名：Dabrafenib[USAN:INN];N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide;UNII-QGP4HA4G1B;Dabrafenib(USAN);Dabrafenib;Tafinlar;N-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide;
分子式：C23H20F3N5O2S2
分子量：519.562
精确质量：519.101
Psa：148.21
UNII号：QGP4HA4G1B
密度：1.4±0.1g/cm3
沸点：653.7±65.0°Cat760mmHg
闪点：349.2±34.3°C
折射率：1.626
储存条件：-20°C
蒸汽压：0.0±2.0mmHgat25°C
简介：Dabrafenib(tradenameTafinlar,GSK2118436)isadrugforthetreatmentofcancersassociatedwithamutatedversionofthegeneBRAF.DabrafenibactsasaninhibitoroftheassociatedenzymeB-Raf,whichplaysaroleintheregulationofcellgrowth.Dabrafenibhasclinicalactivitywithamanageablesafetyprofileinclinicaltrialsofphase1and2inpatientswithBRAF(V600)-mutatedmetastaticmelanoma.
MAPK
