CAS:15639-50-6
15639-50-6
CAS号：15639-50-6
品名：沙芬戈L-threo-Dihydrosphingosine
中文别名：L-苏式-二氢神经鞘氨醇;
英文别名：L-THREO-DIHYDROSPHINGOSINE;L-threo-dihydrosphingosine;L-threosphinganine,2S,3S)L-threo-2-amino-1,3-octadecanediol;
分子式：C18H39NO2
分子量：301.508
精确质量：301.298
Psa：66.48
MDL号：MFCD00792847
密度：0.927 g/cm3
沸点：446.2ºC at 760 mmHg
闪点：223.7ºC
折射率：1.477
储存条件：-20ºC
蒸汽压：7.75E-10mmHg at 25°C
海关编码：2922199090
简介：Safingolisalyso-sphingolipidproteinkinaseinhibitor.IthasthemolecularformulaC18H39NO2andisacolorlesssolid.Medicinally,safingolhasdemonstratedpromisinganticancerpotentialasamodulatorofmulti-drugresistanceandasaninducerofnecrosis.Theadministrationofsafingolalonehasnotbeenshowntoexertasignificanteffectontumorcellgrowth.However,preclinicalandclinicalstudieshaveshownthatcombiningsafingolwithconventionalchemotherapyagentssuchasfenretinide,vinblastine,irinotecanandmitomycinCcandramaticallypotentiatetheirantitumoreffects.CurrentlyinPhaseIclinicaltrials,itisbelievedtobesafetoco-administerwithcisplatin.
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