CAS:141626-36-0
141626-36-0
CAS号：141626-36-0
品名：决奈达隆dronedarone
中文别名：决奈达隆
英文别名：Dronedarone;N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;Multaq;UNII-JQZ1L091Y2;
分子式：C31H44N2O5S
分子量：556.756
精确质量：556.297
Psa：97.23
UNII号：JQZ1L091Y2
密度：1.143 g/cm3
沸点：683.9ºC at 760 mmHg
闪点：367.4ºC
折射率：1.563
蒸汽压：1.47E-18mmHg at 25°C
海关编码：3004909090
简介：Dronedarone(developmentcodenameSR33589andmarketedasMultaq)isadrugbySanofi-Aventis,mainlyfortheindicationofcardiacarrhythmias.ItwasapprovedbytheFDAonJuly2,2009.Itwasrecommendedasanalternativetoamiodaroneforthetreatmentofatrialfibrillationandatrialflutterinpeoplewhoseheartshaveeitherreturnedtonormalrhythmorwhoundergodrugtherapyorelectricshocktreatmenti.e.directcurrentcardioversion(DCCV)tomaintainnormalrhythm.ItisaclassIIIantiarrhythmicdrug.IntheUnitedStates,theFDAapprovedlabelincludesaclaimforreducinghospitalization,butnotforreducingmortality,asareductioninmortalitywasnotdemonstratedintheclinicaldevelopmentprogram.Atrialofthedruginheartfailurewasstoppedasaninterimanalysisshowedapossibleincreaseinheartfailuredeaths,inpatientswithmoderatetosevereCHF.
膜转运/离子通道
