CAS:936727-05-8
936727-05-8
CAS号：936727-05-8
品名：匹莫苯丹Lumacaftor
中文别名：匹莫苯丹
英文别名：VX-809;3-(6-{[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-cyclopropanecarbonyl]-amino}-3-methyl-pyridin-2-yl)-benzoicacid;VX-809(Lumacaftor);3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoicacid;3-[6-[[1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoicacid;
分子式：C24H18F2N2O5
分子量：452.407
精确质量：452.118
Psa：97.75
UNII号：EGP8L81APK
密度：1.517g/cm3
沸点：653.013ºC at 760 mmHg
闪点：348.73ºC
折射率：1.67
简介：Lumacaftor(VX-809)isapharmaceuticaldrugthatactsasachaperoneduringproteinfoldingandincreasesthenumberofCFTRproteinsthataretraffickedtothecellsurface.Itisavailableinasinglepillwithivacaftor;thecombination,lumacaftor/ivacaftor(brandnameOrkambi),isusedtotreatpeoplewithcysticfibrosiswhohavetheF508delmutationinthecysticfibrosistransmembraneconductanceregulator(CFTR),thedefectiveproteinthatcausesthedisease.ItwasdevelopedbyVertexPharmaceuticalsandthecombinationwasapprovedbytheFDAin2015.Asof2015lumacaftorhadnomedicaluseonitsown.
膜转运/离子通道
