CAS:53-96-3
53-96-3
CAS号：53-96-3
品名：N-(2-芴基)乙酰胺2-Acetamidofluorene
中文别名：2-乙酰氨基氟;2-乙酰氨基芴;N-2-芴基乙酰胺;
英文别名：N-(2-Fluorenyl)acetamide;N-(9H-fluoren-2-yl)acetamide;N-2-Fluorenylacetamide;Acetamide,N-9H-fluoren-2-yl-;
分子式：C15H13NO
分子量：223.27
精确质量：223.1
Psa：29.1
RTECS号：AB9450000
MDL号：MFCD00001116
外观与性状：白色粉末
密度：1.23g/cm3
沸点：303ºC
熔点：192-196°C(lit.)
闪点：277.2ºC
折射率：1.656
安全说明：S53-S36/37/39-S45
危险类别码：R23/24/25; R46
WGK Germany：3
海关编码：2924299090
危险品运输编码：UN 3077 9/PG 3
危险类别：6.1(b)
包装等级：III
危险品标志：T
简介：2-Acetylaminofluorene(AAF,2-AAF)isacarcinogenicandmutagenicderivativeoffluorene.Itisusedasabiochemicaltoolinthestudyofcarcinogenesis.Itinducestumorsinanumberofspeciesintheliver,bladderandkidney.Themetabolismofthiscompoundinthebodybymeansofbiotransformationreactionsisthekeytoitscarcinogenicity.2-AAFisasubstrateforcytochromeP-450(CYP)enzyme,whichisapartofasuperfamilyfoundinalmostallorganisms.ThisreactionresultsintheformationofN-hydroxy-2-acetylaminofluorenewhichisaproximalcarcinogenandismorepotentthantheparentmolecule.TheN-hydroxymetaboliteundergoesseveralenzymaticandnon-enzymaticrearrangements.ItcanbeO-acetylatedbycytosolicN-acetyltransferaseenzymetoyieldN-acetyl-N-acetoxyaminofluorene.ThisintermediatecanspontaneouslyrearrangetoformthearylamidoniumionandacarboniumionwhichcaninteractdirectlywithDNAtoproduceDNAadducts.Inadditiontoesterificationbyacetylation,theN-hydroxyderivativecanbeO-sulfatedbycytosolicsulfurtransferaseenzymegivingrisetotheN-acetyl-N-sulfoxyproduct.
用途：1.有机合成。芳香胺类致癌性和诱变性研究。
有机砌块
