CAS:845714-00-3
845714-00-3
CAS号：845714-00-3
品名：1,5,6,7-四氢-2-(4-吡啶基)-4H-吡咯并[3,2-C]吡啶-4-酮2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
中文别名：2-吡啶-4-基-1,5,6,7-四氢吡咯并[3,2-c]吡啶-4-酮;
英文别名：PHA-767491,PHA767491;1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one;2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one;
分子式：C12H12ClN3O
分子量：249.696
精确质量：249.067
Psa：57.78
密度：1.287
沸点：620.6ºC at 760 mmHg
闪点：329.1ºC
储存条件：Desiccate at RT
海关编码：2933990090
简介：PHA767491isapotentandselectiveATP-competitivedualinhibitorcdc7/cdk9.ItblocksDNAsynthesisandaffectsthephosphorylationofthereplicativeDNAhelicaseatCdc7-dependentphosphorylationsites.Inhibitscellproliferationinavarietyofhumancelllinesandinducesapoptosisinap53-independentmannerinvivo.Alsoinhibitsmitogen-activatedproteinkinase-activatedproteinkinase-2(MK-2).
细胞周期
