CAS:518-34-3
518-34-3
CAS号：518-34-3
品名：汉防己甲素D-Tetrandrine
中文别名：(S,S)-(+)-粉防已碱;(1β)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbaman;粉防己碱;
英文别名：sinomeninea;TETRANDRIN;Tetrandrine;hanfangchinA;Trandrine;fanchinine;Conba;6,6',7,12-tetramethoxy-2,2'-dimethyl-berbaman;Jinake;
分子式：C38H42N2O6
分子量：622.75
精确质量：622.304
Psa：61.86
UNII号：29EX23D5AJ
外观与性状：白色固体
密度：1.17 g/cm3 (20ºC)
沸点：710.5ºC at 760 mmHg
熔点：219-222ºC
闪点：175.8ºC
折射率：1.585
稳定性：Stable at normal temperatures and pressures.
储存条件：Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 20ºC.
安全说明：S22-S24/25
危险类别码：R36/37/38
海关编码：2942000000
危险品标志：Xi
简介：Tetrandrineabis-benzylisoquinolinealkaloid,isacalciumchannelblocker.Ithasanti-inflammatory,immunologicandantiallergeniceffects.Itinhibitsthedegranulationofmastcells.Ithasa\"Quinidinelike\"anti-arrhythmiceffect.IthasbeenisolatedfromStephaniatetrandraSMoore,andotherChineseandJapaneseherbs.Ithasvasodilatorypropertiesandcanthereforereducebloodpressure.Tetrandrinemayhavepotentialuseforthetreatmentofliverdiseaseandlivercancer.Tetrandrinehaspotentialtherapeuticvaluetopreventexcessscarring/fibrosisinconjunctivafollowingtrabeculectomyorinpatientswithsevereconjunctivalinflammation.Tetrandrinehasanti-inflammatoryandanti-fibrogenicactions,whichmaketetrandrineandrelatedcompoundspotentiallyusefulinthetreatmentoflungsilicosis,livercirrhosis,andrheumatoidarthritis.TetrandrinehasalsobeenshowntoinhibitentryofEbolavirusintohostcellsinvitroandshowedtherapeuticefficacyagainstEbolainpreliminarystudiesonmice.
用途：抗风湿与镇痛药,用于治疗风湿、高血压、肺癌等病症
中药标准品
