CAS:133407-82-6
133407-82-6
CAS号：133407-82-6
品名：MG-132
中文别名：Z-LEU-LEU-LEU-AL;蛋白酶体抑制剂;
英文别名：Z-Leu-Leu-Leu-H;benzylN-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate;Z-LLL-CHO;Cbz-Leu-Leu-Leu-H;Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal;Z-Leu-Leu-Leu-CHO;
分子式：C26H41N3O5
分子量：475.621
精确质量：475.305
Psa：113.6
MDL号：MFCD00674886
PubChem号：24892475
外观与性状：白色至灰白色粉末
密度：1.073 g/cm3
沸点：682ºC at 760 mmHg
闪点：366.3ºC
折射率：1.506
储存条件：-20ºC
蒸汽压：1.86E-18mmHg at 25°C
简介：MG132isaspecific,potent,reversible,andcell-permeableproteasomeinhibitor(Ki=4nM).Itreducesthedegradationofubiquitin-conjugatedproteinsinmammaliancellsandpermeablestrainsofyeastbythe26ScomplexwithoutaffectingitsATPaseorisopeptidaseactivities.MG132activatesc-JunN-terminalkinase(JNK1),whichinitiatesapoptosis.MG132alsoinhibitsNF-κBactivationwithanIC50of3µMandpreventsβ-secretasecleavage.
蛋白酶
