CAS:935888-69-0
935888-69-0
CAS号：935888-69-0
品名：OprozomibN-[(2S)-3-methoxy-1-[[(2S)-3-methoxy-1-[[(2S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-2-methyl-1,3-thiazole-5-carboxamide
中文别名：Oprozomib
英文别名：ONX-0912;QC-9273;Oprozomib;PR-047;
分子式：C25H32N4O7S
分子量：532.609
精确质量：532.199
Psa：186.96
UNII号：MZ37792Y8J
密度：
简介：Oprozomib(INN,codenamedONX0912andPR-047)isanorallyactivesecond-generationproteasomeinhibitordevelopedbyOnyxPharmaceuticals,anAmgensubsidiary.Itisbeinginvestigatedforthetreatmentofhematologicmalignancies,specifically,multiplemyeloma,withPhase1bstudiesongoing(asofFebruary16,2016).Beinganepoxyketonederivative,oprozomibisstructurallyrelatedtocarfilzomibandhastheaddedbenefitofbeingorallybioavailable.Itselectivelyinhibitschymotrypsin-likeactivityofboththeconstitutiveproteasome(PSMB5)andimmunoproteasome(LMP7).Likecarfilzomib,itisactiveagainstbortezomib-resistantmultiplemyelomacells.
蛋白酶
