CAS:936091-26-8
936091-26-8
CAS号：936091-26-8
品名：N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺N-tert-butyl-3-[[5-methyl-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]pyrimidin-4-yl]amino]benzenesulfonamide
中文别名：N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-[2-(1-吡咯烷基)乙氧基]苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺
英文别名：N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide;N-(1,1-Dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]benzenesulfonamide;2TA;Fedratinib;
分子式：C27H36N6O3S
分子量：524.678
精确质量：524.257
Psa：120.09
MDL号：MFCD12922515
密度：1.247g/cm3
沸点：713.7ºC at 760 mmHg
闪点：385.5ºC
简介：TG101348(SAR302503)isanorallyavailableinhibitorofJanuskinase2(JAK-2)developedforthetreatmentofpatientswithmyeloproliferativediseasesincludingmyelofibrosis.TG101348actsasacompetitiveinhibitorofproteinkinaseJAK-2withIC50=6nM;relatedkinasesFLT3andRETarealsosensitive,withIC50=25nMandIC50=17nM,respectively.SignificantlylessactivitywasobservedagainstothertyrosinekinasesincludingJAK3(IC50=169nM).Intreatedcellstheinhibitorblocksdownstreamcellularsignalling(JAK-STAT)leadingtosuppressionofproliferationandinductionofapoptosis.
JAK/STAT
