CAS:152044-54-7
152044-54-7
CAS号：152044-54-7
品名：埃博霉素BepothiloneB
中文别名：帕土匹龙;
英文别名：(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione;EpothiloneB(EPO906,Patupilone);EpothilonB;GNF-PF-193;EpoB;Patupilone;EpothiloneB;EPO906;EPO906,EpoB,Patupilone;
分子式：C27H41NO6S
分子量：507.683
精确质量：507.265
Psa：137.49
UNII号：UEC0H0URSE
外观与性状：白色粉末
密度：1.136
沸点：680.2ºC at 760mmHg
熔点：95-97ºC
闪点：365.2ºC
折射率：1.532
蒸汽压：0mmHg at 25°C
简介：Epothilonesarepolyketidenaturalproductsthatinhibitcancercellsbyamechanismsimilartopaclitaxel,andalsoareeffectiveagainstpaclitaxel-resistanttumours.EpothiloneBiswhatisknownasamicrotubulestabilizer.Whenacelldivides,thechromosomesthatwillendupineachcellareseparatedbythinfilamentscalledmicrotubules.Normallythesemicrotubulesthenbreakdownasthecelldivisionprogresses.Thisclassofcytotoxicchemodrugspreventsthatbreakdownandthuspreventscellsfromcompletingdivision.
抗生素
