CAS:917879-39-1
917879-39-1
CAS号：917879-39-1
品名：N-[(2R)-1,4-二恶烷-2-基甲基]-N-甲基-N'-[3-(1-甲基-1H-吡唑-4-基)-5-氧代-5H-苯并[4,5]环庚并[1,2-b]吡啶-7-基]硫酸二酰胺9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
中文别名：N-[(2R)-1,4-二恶烷-2-基甲基]-N-甲基-N'-[3-(1-甲基-1H-吡唑-4-基)-5-氧代-5H-苯并[4,5]环庚并[1,2-b]吡啶-7-基]硫酸二酰胺
英文别名：MK-2461;UNII-4200RD53XF;Sulfamide,N-((2R)-1,4-dioxan-2-ylmethyl)-N-methyl-N'-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl);
分子式：C24H25N5O5S
分子量：495.551
精确质量：495.158
Psa：124.03
UNII号：4200RD53XF
密度：1.45 g/cm3
沸点：732.4ºC at 760 mmHg
闪点：396.7ºC
简介：MK-2461isanovelATP-competitivemultitargetedkinaseinhibitorthatpreferentiallyinhibitstheactivatedc-Metreceptor.MK-2461isalsoapotentinhibitorofRon,Flt1,Flt3,PDGFRβ,andMerreceptors.RecentstudiesshowthatMK-2461siginifciantlysuppressestumorgrowthofGTL-16xenograftsinmiceandMK-2461treatmentseffectivelyinhibitthegrowthofNIH3T3tumorsharboringc-MetsinglenucleotidemutantsT3936CandT3997C.
蛋白酪氨酸激酶
