CAS:1032900-25-6
1032900-25-6
CAS号：1032900-25-6
品名：色瑞替尼Ceritinib
中文别名：5-氯-N2-(2-异丙氧基-5-甲基-4-(哌啶-4-基)苯基)-N4-(2-(异丙基磺酰基)苯基)嘧啶-2,4-二胺;
英文别名：CS-1406;LDK378;5-chloro-N2-(2-isopropoxy-5-methyl-4-piperidin-4-ylphenyl)-N4-[2-(isopropylsulfonyl)phenyl]-pyrimidine-2,4-diamine;Ceritinib(LDK378);5-chloro-2-N-(5-methyl-4-piperidin-4-yl-2-propan-2-yloxyphenyl)-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine;5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine;S7083,LDK378;LDK378||LDK-378;LDK378;QC-5183;
分子式：C28H36ClN5O3S
分子量：558.135
精确质量：557.223
Psa：116.85
UNII号：K418KG2GET
密度：1.3±0.1g/cm3
沸点：720.7±70.0°Cat760mmHg
闪点：389.6±35.7°C
折射率：1.595
储存条件：室温，干燥，密封
蒸汽压：0.0±2.3mmHgat25°C
简介：Ceritinib(INN,tradenameZykadia)isadrugforthetreatmentofaspecifictypeoflungcancer.Itisananaplasticlymphomakinase(ALK)inhibitor.ItwasdevelopedbyNovartis.ItwasapprovedinApril2014bytheFoodandDrugAdministrationforthetreatmentofALK-positivemetastaticnon-smallcelllungcancer(NSCLC)inpatientsthatfailedtreatmentwithcrizotinib.Itisamoreeffective,butmoretoxic,alternativetotraditionalplatinum-basedchemotherapies.CeritinibwasfoundatphysiologicalconcentrationstoinhibitALK,insulin-likegrowthfactor1receptor(IGF-1R),andROS1.
蛋白酪氨酸激酶
