CAS:670220-88-9
670220-88-9
CAS号：670220-88-9
品名：[1-[2-[5-(3-甲基氧杂环丁烷-3-基甲氧基)苯并咪唑-1-基]喹啉-8-基]哌啶-4-基]胺1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
中文别名：罗通定.左旋延胡索乙素;
英文别名：Crenolanib[USAN:INN];ARO-002;Crenolanib;1-{2-[5-(3-methyloxetan-3-ylmethoxy)benzoimidazol-1-yl]quinolin-8-yl}piperidin-4-ylamine;Crenolanib[USAN];UNII-LQF7I567TQ;
分子式：C26H29N5O2
分子量：443.541
精确质量：443.232
Psa：78.43
MDL号：MFCD21609260
密度：1.36
简介：Crenolanibbesylate(CP-868,596-26;4-piperidinamine,1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-,monobenzenesulfonate)isaninvestigationalinhibitorbeingdevelopedbyAROGPharmaceuticals,LLC.Thecompoundiscurrentlybeingevaluatedforsafetyandefficacyinclinicaltrialsforvarioustypesofcancer,includingacutemyeloidleukemia(AML),gastrointestinalstromaltumor(GIST),andglioma.Crenolanibisanorallybioavailablebenzamidazolethatselectivelyandpotentlyinhibitssignalingofwild-typeandmutantisoformsofclassIIIreceptortyrosinekinases(RTK)FLT3(FMS-likeTyrosineKinase3),PDGFRα(Platelet-DerivedGrowthFactorReceptor),andPDGFRβ.UnlikemostRTKinhibitors,crenolanibisatypeImutant-specificinhibitorthatpreferentiallybindstophosphorylatedactivekinaseswiththe‘DFGin’conformationmotif.
蛋白酪氨酸激酶
