CAS:714971-09-2
714971-09-2
CAS号：714971-09-2
品名：[4-[[1-[(3-氟苯基)甲基]-1H-咪唑-5-基]氨基]-5-甲基吡咯[2,1-f][1,2,4]三嗪-6-基]-氨基甲酸-(3S)-3-吗啉甲酯[(3S)-morpholin-3-yl]methylN-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate
中文别名：[4-[[1-[(3-氟苯基)甲基]-1H-咪唑-5-基]氨基]-5-甲基吡咯[2,1-f][1,2,4]三嗪-6-基]-氨基甲酸-(3S)-3-吗啉甲酯
英文别名：[4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]-carbamicacid;[4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamicacid(3S)-3-morpholinylmethylester;(S)-Morpholin-3-ylmethyl(4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate;(S)-morpholin-3-ylmethyl-4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrolo[1,2-f][1,2,4]triazin-6-ylcarbamate;(3S)-3-morpholinylmethylester;[4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-yl]carbamicacid(3S)-3-morpholinylmethylester;
分子式：C27H27FN8O3
分子量：530.553
精确质量：530.219
Psa：119.63
密度：1.484 g/cm3
简介：ItisahighlyselectiveandpotentinhibitorofHER1andHER2kinasesandinhibitstumorcellproliferationthroughmodulationofreceptorsignaling.BMS-599626inhibitsHER1/HER2receptorheterodimerizationandprovidesanadditionalmechanismofinhibitingtumorsinwhichreceptorcoexpressionandheterodimerizationplayamajorroleindrivingtumorgrowth.
蛋白酪氨酸激酶
