CAS:811803-05-1
811803-05-1
CAS号：811803-05-1
品名：阿帕替尼Apatinib
中文别名：N-[4-(1-氰基环戊基)苯基]-2-[(4-吡啶甲基)氨基]-3-吡啶甲酰胺;
英文别名：YN968D1;3-Pyridinecarboxamide,N-[4-(1-cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-;N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide;N-[4-(1-cyanocyclopentyl)phenyl]-2-(4-pyridylmethyl)amino-3-pyridinecarboxyamide;N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide;W-5938;
分子式：C24H23N5O
分子量：397.472
精确质量：397.19
Psa：90.7
MDL号：MFCD21648511
密度：
简介：Apatinibisanorallyavailable,smallmoleculemultitargetedtyrosinekinaseinhibitor.Apatinibselectivelyinhibitsthevascularendothelialgrowthfactorreceptor-2(VEGFR2).ApatinibfunctionsbyinhibitingVEGF-mediatedendothelialcellmigrationandproliferationthusblockingnewbloodvesselformationintumortissue.RecentstudieshaveshownthatApatinibenhancestheefficacyofconventionalchemotherapeuticaldrugsinsidepopulation(SP)cellsandABCB1-overexpressingleukemiacells.
蛋白酪氨酸激酶
