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CAS:763113-22-0
763113-22-0
CAS号：763113-22-0
品名：奥拉帕尼olaparib
中文别名：奥拉帕尼
英文别名：AZD-2281;azd2281Olaparib;
分子式：C24H23FN4O3
分子量：434.463
精确质量：434.175
Psa：86.37
MDL号：MFCD13185161
密度：1.43
折射率：1.702
海关编码：2933990090
简介：Olaparib(AZD-2281,tradenameLynparza)isanFDA-approvedtargetedtherapyforcancer,developedbyKuDOSPharmaceuticalsandlaterbyAstraZeneca.ItisaPARPinhibitor,inhibitingpolyADPribosepolymerase(PARP),anenzymeinvolvedinDNArepair.ItactsagainstcancersinpeoplewithhereditaryBRCA1orBRCA2mutations,whichincludesomeovarian,breast,andprostatecancers.InDecember2014,olaparibwasapprovedforuseasasingleagentbytheEMAandtheFDA.TheFDAapprovalisinforgermlineBRCAmutated(gBRCAm)advancedovariancancerthathasreceivedthreeormorepriorlinesofchemotherapy.
DNA损伤
