CAS:1219168-18-9
1219168-18-9
CAS号：1219168-18-9
品名：Dorsomorphin2HCl6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine,dihydrochloride
中文别名：Dorsomorphin2HCl
英文别名：6-[4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-3-(4-PYRIDINYL)-PYRAZOLO[1,5-A]PYRIMIDINEDIHYDROCHLORIDE;Dorsomorphin2HCl;FD5027;Dorsomorphindihydrochloride;S7306,BML-275,CompoundC;
分子式：C24H27Cl2N5O
分子量：472.41
精确质量：471.159
Psa：55.55
密度：
储存条件：室温，干燥，密封
简介：DorsomorphinisanAMP-activatedkinase(AMPK)inhibitor.Dorsomorphinselectivelyinhibitsthebonemorphogeneticprotein(BMP)typeIreceptorsALK2,ALK3andALK6andthusblocksBMP-mediatedSMAD1/5/8phosphorylation,targetgenetranscriptionandosteogenicdifferentiation.Dorsomorphinhasshowntotoincreasecisplatin-inducedapoptosis,whichwasassociatedwithhyper-inductionofthetumorsuppressorp53.
PI3K/Akt/mTOR
