CAS:97322-87-7
97322-87-7
CAS号：97322-87-7
品名：曲格列酮Troglitazone
中文别名：5-[[4-[(3,4-二氢-6-羟基-2,5,7,8-四甲基-2H-1-苯并吡喃-2-基)甲氧基]苯基]甲基]-2,4-噻唑烷二酮;特洛格列酮;(+/-)-5-[4-[(6-羟基-2,5,7,8-四甲基苯并二氢吡喃-2-基)甲氧基]苄基]-2,4-噻唑烷二酮;
英文别名：Prelay;Romglizone;5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]-benzyl]-2,4-thiazolidinedione;5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidine;5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)-benzyl]thiazolidine-2,4-dione;Rezulin(TN);CS-045;Rezulin;Romozin;Noscal;5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;Resulin;
分子式：C24H27NO5S
分子量：441.54
精确质量：441.161
Psa：110.16
RTECS号：XJ5813130
UNII号：I66ZZ0ZN0E
外观与性状：黄色固体
密度：1.266g/cm3
沸点：657ºC at 760mmHg
熔点：184-186°C
闪点：351.2ºC
稳定性：This material is stable if stored as directed.
储存条件：This product should be stored at room temperature. It should be kept in a tightly closed container.
安全说明：S22-S24/25
WGK Germany：2
简介：Troglitazone(Rezulin,Resulin,Romozin,Noscal)isanantidiabeticandanti-inflammatorydrug,andamemberofthedrugclassofthethiazolidinediones.Itwasprescribedforpatientswithdiabetesmellitustype2.ItwasdevelopedbyDaiichiSankyo(Japan).IntheUnitedStates,itwasintroducedandmanufacturedbyParke-Davisinthelate1990s,butturnedouttobeassociatedwithanidiosyncraticreactionleadingtodrug-inducedhepatitis.TheF.D.A.medicalofficerassignedtoevaluatetroglitazone,JohnGueriguian,didnotrecommenditsapprovalduetopotentialhighlivertoxicity;Parke-DaviscomplainedtotheFDAandGuerigianwassubsequentlyremovedfromhispost.AfullpanelofexpertsapproveditinJanuary1997.Oncetheprevalenceofadverselivereffectsbecameknown,troglitazonewaswithdrawnfromtheBritishmarketinDecember1997,fromtheUnitedStatesmarketin2000,andfromtheJapanesemarketsoonafterwards.ItdidnotgetapprovalintherestofEurope.
用途：噻唑烷酮类口服抗高血糖药。用于因产生耐受而单独使用胰岛素难控制的Ⅱ型糖尿病。
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