CAS:637-58-1
637-58-1
CAS号：637-58-1
品名：盐酸普莫卡因Pramoxinehydrochloride
中文别名：普莫卡因;
英文别名：4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride;Morpholine,4-[3-(4-butoxyphenoxy)propyl]-,hydrochloride;
分子式：C17H28ClNO3
分子量：329.862
精确质量：329.176
Psa：30.93
RTECS号：QD8750000
UNII号：88AYB867L5
外观与性状：白色或灰白色结晶粉末
密度：
沸点：427ºC at 760 mmHg
熔点：181-183ºC
闪点：123.5ºC
安全说明：S26-S36
危险类别码：R22; R36/37/38
海关编码：2934999090
危险品标志：Xi
简介：Pramocaine(INNandBAN,alsoknownaspramoxineorpramoxineHCI)isatopicalanestheticdiscoveredatAbbottLaboratoriesin1953andusedasanantipruritic.Chemically,itisp-nbutoxyphenylgammamorpholinopropyletherhydrochloride.Duringresearchanddevelopment,pramoxinehydrochloridestoodoutamongaseriesofalkoxyarylalkamineethersasanespeciallygoodtopicallocalanestheticagent.Pharmacologicstudyrevealedittobepotentandoflowacuteandsubacutetoxicity,welltoleratedbymostmucousmembranesandofalowsensitizingindexinhumans.Likeotherlocalanesthetics,paramoxinedecreasesthepermeabilityofneuronalmembranestosodiumions,blockingbothinitiationandconductionofnerveimpulses.Depolarizationandrepolarizationofexcitableneuralmembranesisthusinhibited,leadingtonumbness.
用途：局部麻醉药。
其他分子
