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CAS:202475-60-3
202475-60-3
CAS号：202475-60-3
品名：4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉Janex1
中文别名：4-(4-羟基苯胺)-6,7-二甲氧基喹唑啉
英文别名：1-Amino-4-&<4-hydroxy-anilino&>-anthrachinon-2-sulfonsaeure;
分子式：C16H15N3O3
分子量：297.309
精确质量：297.111
Psa：76.5
MDL号：MFCD01862614
密度：1.3±0.1g/cm3
沸点：468.1±40.0°Cat760mmHg
闪点：236.9±27.3°C
折射率：1.689
储存条件：-20℃
蒸汽压：0.0±1.2mmHgat25°C
简介：Janex1isaJanustyrosinekinase3(JAK3)inhibitor.InhibitionofJAK3hasbeenshowntoexhibitprotectiveactionagainstthedevelopmentofT1Dinnon-obesediabetic(NOD)mice.Janex1hasbeenshowntosuppressesproliferationofshort-termculturedNODCD4+Tcellsthroughinductionofapoptosis,whilepromotingsurvivalofaparticularpopulationoflong-termculturedcells.ItamelioratestheexpressionofTNF-α-inducedcelladhesionmoleculesandimprovesmyocardialvascularpermeability.
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