CAS:125464-42-8
125464-42-8
CAS号：125464-42-8
品名：β-(氨基甲基)-4氯代苯乙烷磺酸3-Amino-2-(4-chlorophenyl)propane-1-sulfonicacid
中文别名：3-氨基-2-(4-氯苯基-丙烷磺酸;Β-(氨甲基)-4氯代苯乙烷磺酸;Beta-(氨基甲基)-4氯代苯乙烷磺酸;
英文别名：3-amino-2-(4-chlorophenyl)propane-1-sulfonicacid;
分子式：C9H12ClNO3S
分子量：249.714
精确质量：249.023
Psa：88.77
MDL号：MFCD00216817
外观与性状：白色结晶固体
密度：1.437 g/cm3
折射率：1.6
WGK Germany：3
海关编码：2921499090
简介：SaclofenisacompetitiveantagonistfortheGABABreceptor.ThisdrugisananalogueoftheGABABagonistbaclofen.TheGABABreceptorisheptahelicalreceptor,expressedasanobligateheterodimer,whichcouplestotheGi/oclassofheterotrimericG-proteins.Theactionofsaclofenonthecentralnervoussystemisunderstandablymodest,becauseG-proteinsrelyonanenzymecascadetoaltercellbehaviorwhileionotropicreceptorsimmediatelychangetheionicpermeabilityoftheneuronalplasmamembrane,thuschangingitsfiringpatterns.Theseparticularreceptors,presynapticallyinhibitN-andP/Q-voltage-gatedcalciumchannels(VGCCs)viaadirectinteractionofthedissociatedbetagammasubunitoftheg-proteinwiththeintracellularloopbetweenthe1stand2nddomainoftheVGCC'salpha-subunit;postsynaptically,thesepotentiateKircurrents.Bothresultininhibitoryeffects.
化学连接
