CAS:956104-40-8
956104-40-8
CAS号：956104-40-8
品名：ARN509ARN-509
中文别名：ARN509
英文别名：Benzamide,4-[7-[6-cyano-5-(trifluoromethyl)-3-pyridinyl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methyl;4-(7-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro(3.4)octan-5-yl)-2-fluoro-N-methylbenzamide;4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide;4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;N-methyl-4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl]-2-fluorobenzamide;4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide;QCR-211;
分子式：C21H15F4N5O2S
分子量：477.435
精确质量：477.088
Psa：121.42
MDL号：MFCD28142762
密度：1.6±0.1g/cm3
折射率：1.659
储存条件：-20°C
简介：Apalutamide(INN)(developmentalcodenameARN-509,alsoJNJ-56021927)isanon-steroidalantiandrogenthatisunderdevelopmentforthetreatmentofprostatecancer.Itissimilartoenzalutamidebothstructurallyandpharmacologically,actingasaselectivecompetitiveantagonistoftheandrogenreceptor(AR),butshowssomeadvantages,includinggreaterpotencyandreducedcentralnervoussystempermeation.ApalutamidebindsweaklytotheGABAAreceptorsimilarlytoenzalutamide,butduetoitsrelativelylowercentralconcentrations,mayhavealowerriskofseizuresincomparison.
其他分子
