CAS:163451-81-8
163451-81-8
CAS号：163451-81-8
品名：特立氟胺teriflunomide
中文别名：(Z)-2-氰基-3-羟基-N-(4-(三氟甲基)苯基)丁-2-烯酰胺;A771726;Aubagio;(2Z)-2-氰基-3-羟基-N-[4-(三氟甲基)苯基]丁-2-烯酰胺;
英文别名：(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide;(Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)but-2-enamide;Teriflunomide;
分子式：C12H9F3N2O2
分子量：270.207
精确质量：270.062
Psa：73.12
密度：1.4±0.1g/cm3
沸点：410.8±45.0°Cat760mmHg
闪点：202.3±28.7°C
折射率：1.552
储存条件：-20°C
蒸汽压：0.0±1.0mmHgat25°C
海关编码：2942000000
信号词：Warning
危险标志：GHS07
危险性描述：H302
简介：Teriflunomide(tradenameAubagio,marketedbySanofi)istheactivemetaboliteofleflunomide.TeriflunomidewasinvestigatedinthePhaseIIIclinicaltrialTEMSOasamedicationformultiplesclerosis(MS).ThestudywascompletedinJuly2010.2-yearresultswerepositive.However,thesubsequentTENEREhead-to-headcomparisontrialreportedthat\"althoughpermanentdiscontinuations[oftherapy]weresubstantiallylesscommonamongMSpatientswhoreceivedteriflunomidecomparedwithinterferonbeta-1a,relapsesweremorecommonwithteriflunomide.\"ThedrugwasapprovedbytheFDAonSeptember13,2012andintheEuropeanUniononAugust26,2013.
其他分子
