CAS号:238750-77-1
品名:托舍多特Tosedostat
中文别名:ALPHA-[[(2R)-2-[(1S)-1-羟基-2-(羟基氨基)-2-氧代乙基]-4-甲基-1-氧代戊基]氨基]苯乙酸环戊酯;他达拉非;
英文别名:cyclopentyl(2S)-2-[[(2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate;CHR2797-Tosedostat;CHR-2797;UNII-KZK563J2UW;
分子式:C21H30N2O6
分子量:406.473
精确质量:406.21
Psa:124.96
密度:1.24
折射率:1.566
简介:CHR-2797isanovelmetalloenzymeinhibitorthatisconvertedintoapharmacologicalactiveacidproduct(CHR-79888)insidecells.CHR-2797exertsantiproliferativeeffectsagainstarangeoftumorcelllinesinvitroandinvivoandshowsselectivityfortransformedovernontransformedcells.Itsantiproliferativeeffectsareatleast300timesmorepotentthantheprototypicalaminopeptidaseinhibitor,Bestatin.
代谢