Nav
CAS:192185-72-1
192185-72-1
CAS号：192185-72-1
品名：替吡法尼6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
中文别名：(R)-6-(氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基)-4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮;
英文别名：Tipifarnib(Zarnestra);Zarnestra;Tipifarnib;
分子式：C27H22Cl2N4O
分子量：489.396
精确质量：488.117
Psa：65.84
UNII号：MAT637500A
外观与性状：灰白色至淡米色固体
密度：1.33g/cm3
沸点：681.7ºC at 760mmHg
熔点：211-213ºC (dec.)
闪点：366.1ºC
折射率：1.671
蒸汽压：1.94E-18mmHg at 25°C
简介：Afarnesyltransferaseinhibitor.Sensitizeshumanmultiplemyelomacelltoproteasomeinhibitionbyblockingdegradationofbortezomib(B675700)-inducedaggresomes.Alsoshowntoinhibitthegrowthofmyeloidleukemiacelllinesandprimaryleukemiacellsbyinducingapoptosisandcell-cycleblockagewhencombinedwithrapamycin(R124000).
代谢
