CAS:868273-06-7
868273-06-7
CAS号：868273-06-7
品名：5-氯-3-乙基-N-[2-[4-(1-哌啶基)苯基]乙基-1H-吲哚-2-甲酰胺5-chloro-3-ethyl-N-[2-(4-piperidin-1-ylphenyl)ethyl]-1H-indole-2-carboxamide
中文别名：盐酸毛果芸香碱;5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺;
英文别名：CS-0514;
分子式：C24H28ClN3O
分子量：409.952
精确质量：409.192
Psa：48.13
密度：1.218g/cm3
沸点：660.3ºC at 760 mmHg
闪点：353.2ºC
折射率：1.635
储存条件：2-8ºC
危险类别码：R22
海关编码：2933990090
危险品标志：Xn
简介：Org27569isadrugwhichactsasapotentandselectivepositiveallostericmodulatorofthecannabinoidCB1receptor.StudiesinvitrosuggestthatitbindstoaregulatorysiteontheCB1receptortarget,causingaconformationalchangethatincreasesthebindingaffinityofCB1agonistssuchasCP55,940,whiledecreasingthebindingaffinityofCB1antagonistsorinverseagonistssuchasrimonabant.HoweverwhileOrg27569increasestheabilityofCB1agoniststobindtothereceptor,itdecreasestheirefficacyatstimulatingsecondmessengersignallingoncebound,andsoinpracticebehavesasaninsurmountableantagonistofCB1receptorfunction.
G蛋白偶联受体&G蛋白
