CAS:441798-33-0
441798-33-0
CAS号：441798-33-0
品名：马西替坦macitentan
中文别名：N-[5-(4-溴苯基)-6-[2-[(5-溴-2-嘧啶基)氧]乙氧基]-4-嘧啶基]-N'-丙基磺酰胺;
英文别名：Macitentan;5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine;Actelion-1;Opsumit;
分子式：C19H22Br2N6O4S
分子量：590.289
精确质量：587.979
Psa：159.84
MDL号：MFCD17167076
密度：1.675
沸点：692.397ºC at 760 mmHg
闪点：372.548ºC
简介：Macitentan(tradenameOpsumit)isanendothelinreceptorantagonist(ERA)approvedforthetreatmentofpulmonaryarterialhypertension(PAH).TheothertwoERAsmarketedasof2014arebosentanandambrisentan.MacitentanisadualERA,meaningthatitactsasanantagonistoftwoendothelin(ET)receptorsubtypes,ETAandETB.However,macitentanhasa50-foldincreasedselectivityfortheETAsubtypecomparedtotheETBsubtype.ThedrugreceivedapprovalfromtheU.S.FoodandDrugAdministration(FDA)onOctober13,2013.
G蛋白偶联受体&G蛋白
