CAS:141801-26-5
141801-26-5
CAS号：141801-26-5
品名：内吗啡-2Endomorphin2
中文别名：TYR-PRO-PHE-PHE-NH2;
英文别名：H-Tyr-Pro-Phe-Phe-NH2;(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide;
分子式：C32H37N5O5
分子量：571.667
精确质量：571.279
Psa：167.85
UNII号：3PH5M0466G
密度：1.292g/cm3
沸点：972.4ºC at 760mmHg
闪点：541.9ºC
折射率：1.632
储存条件：-20ºC
蒸汽压：0mmHg at 25°C
简介：Endomorphin-2(EM-2)(aminoacidsequenceTyr-Pro-Phe-Phe-NH2)isanendogenousopioidpeptideandoneofthetwoendomorphins.Itisahighaffinity,highlyselectiveagonistoftheμ-opioidreceptor,andalongwithendomorphin-1(EM-1),hasbeenproposedtobetheactualendogenousligandofthisreceptor(thatis,ratherthantheendorphins).LikeEM-1,EM-2producesanalgesiainanimals,butwhereasEM-1ismoreprevalentinthebrain,EM-2ismoreprevalentinthespinalcord.Inaddition,theactionofEM-2differsfromthatofEM-1somewhat,becauseEM-2additionallyinducesthereleaseofdynorphinAand[Met]enkephalininthespinalcordandbrainbyanunknownmechanism,whichinturngoontoactivatetheκ-andδ-opioidreceptors,respectively,andaportionoftheanalgesiceffectsofEM-2isdependentonthisaction.Moreover,whileEM-1producesconditionedplacepreference,ameasureofdrugreward,EM-2producesconditionedplaceaversion,aneffectwhichisdynorphinA-dependent.SimilarlytothecaseofEM-1,thegeneencodingforEM-2hasnotyetbeenidentified.
细胞信号和神经生物学
