CAS:15585-43-0
15585-43-0
CAS号：15585-43-0
品名：RJR2403;(E)-位变异烟碱(3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine
中文别名：RJR2403;(E)-位变异烟碱
英文别名：(E)-N-methyl-4-(3-pyridinyl)-3-butene-1-amine;(E)-N-methyl-4-(3-(pyridin)yl)-3-buten-1-amine;ritodrine(erythro);Metanicotin;trans-metanicotine;Rivanicline;
分子式：C10H14N2
分子量：162.232
精确质量：162.116
Psa：24.92
UNII号：6H35LF645A
密度：
沸点：121 - 122 °C (3 mmHg)
简介：Rivanicline(TC-2403,RJR-2403,(E)-metanicotine)isadrugwhichactsasapartialagonistatneuralnicotinicacetylcholinereceptors.Itissubtype-selective,bindingprimarilytotheα4β2subtype.IthasnootropiceffectsandwasoriginallydevelopedasapotentialtreatmentforAlzheimer'sdisease,butasecondactionthatwassubsequentlyfoundwasthatitinhibitstheproductionofInterleukin-8andthusproducesanantiinflammatoryeffect,andsoithasalsobeendevelopedasapotentialtreatmentforulcerativecolitis.Rivaniclinealsohasstimulantandanalgesicactionswhicharethoughttobemediatedthroughstimulationofnoradrenalinerelease,andsoitcouldpotentiallyalsohaveotherapplications.
神经信号
