CAS:218600-53-4
218600-53-4
CAS号：218600-53-4
品名：2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯methyl(4aS,6aR,6bS,8aR,12aS,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicene-4a-carboxylate
中文别名：CDDO孤儿药;
英文别名：Bardoxolone(methyl);2-cyano-3-thien-2-ylprop-2-enethioamide;(2E)-2-Cyano-3-(2-thienyl)-2-propenethioamide;2-cyano-3-(thiophen-2-yl)thioacrylamide;2-cyano-3-(2-thienyl)-2-propenethioamide;2-Cyano-3-(2-thienyl)thioacrylamide;Propenethiamide,2-cyano-3-(2-thienyl);2-cyano-3,12-dioxooleane-1,9(11)-dien-28-oicacidmethylester;2-cyano-3,12-dioxooleana-1,9(11)-dien-28-acidmethylester;BardoxoloneMethyl;2-cyano-3,12-dioxoolean-1,9-dien-28-oicacid,methylester;(E)-2-cyano-3-thiophen-2-yl-thioacrylamide;2-cyano-3,12-dioxoolean-1,9(11)-dien-28-oicacidmethylester;
分子式：C32H43NO4
分子量：505.688
精确质量：505.319
Psa：84.23
MDL号：MFCD11983137
密度：1.15g/cm3
沸点：600.8ºC at 760mmHg
闪点：256.5ºC
折射率：1.558
蒸汽压：2.15E-14mmHg at 25°C
海关编码：2926909090
简介：CDDOMethylEsterisasynthetictriterpenoidthatinhibitsIκBαkinaseandenhancesapoptosisinducedbyTNFandchemotherapeuticagentsthroughdown-regulationofexpressionofnuclearfactorκB-regulatedgeneproductsinhumanleukemiccells.CDDOMethylEsterisanoveltherapeuticagentinthetreatmentofacutemyeloidleukemiaandinthetreatmentofpancreaticcanceraswellasotherformsofcancer.
NF-kB
