CAS:927880-90-8
927880-90-8
CAS号：927880-90-8
品名：RAF265;1-甲基-5-[[2-[5-(三氟甲基)-1H-咪唑-2-基]-4-吡啶基]氧基]-N-[4-(三氟甲基)苯基]-1H-苯并咪唑-2-胺1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
中文别名：RAF265;1-甲基-5-[[2-[5-(三氟甲基)-1H-咪唑-2-基]-4-吡啶基]氧基]-N-[4-(三氟甲基)苯基]-1H-苯并咪唑-2-胺
英文别名：{1-methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yIoxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethyl-phenyl)amine;{1-Methyl-5-[2-(5-trifluoromethyl-1H-imidazol-2-yl)-pyridin-4-yloxy]-1H-benzoimidazol-2-yl}-(4-trifluoromethylphenyl)-amine;1-methyl-5-(2-(5-(trifluoromethyl)-1H-imidazol-2-yl)pyridin-4-yloxy)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazol-2-amine;,CHIR-265,,CHIR265;RAF265;RAF265(CHIR-265);1-Methyl-5-[[2-[5-(trifluoromethyl)-1h-imidazol-2-yl]-4-pyridinyl]oxy]-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine;CHIR265;
分子式：C24H16F6N6O
分子量：518.414
精确质量：518.129
Psa：80.65
MDL号：MFCD16659061
密度：1.5±0.1g/cm3
沸点：667.6±65.0°Cat760mmHg
闪点：357.5±34.3°C
折射率：1.622
储存条件：-20℃
蒸汽压：0.0±2.0mmHgat25°C
简介：RAF265isamultikinaseinhibitorthathasdisplayedBRAFinhibitingactivityinclinicaltrials.Itcouldbeusedinthetreatmentofasubpopulationofhumanmelanomatumors.HascytotoxiceffectofonMDA-MB-231cells.RAF265whenusedwithBEZ-235inhibitedERK,PI3Ksignalingthatreducedgrowth,proliferationanddevelopmentofdrugresistanceinhumanthyroidcancercells.
MAPK
