CAS:188968-51-6
188968-51-6
CAS号：188968-51-6
品名：西仑吉肽2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]aceticacid
中文别名：环(L-精氨酰甘氨酰-L-天冬氨酰-D-苯丙氨酰-N-甲基-L-缬氨酰);倍他司汀二盐酸盐;Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl);
英文别名：cyclo(arginyl-glycyl-aspartyl-D-phenylalanyl-N-methyl-valyl);cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl);cyclo[-Arg-Gly-Asp-D-Phe-N-MeVal-];Cilengitide;Cilengitide[USAN:INN];cyclo(RGDf-N(Me)V-);
分子式：C27H40N8O7
分子量：588.656
精确质量：588.302
Psa：235.91
MDL号：MFCD04307743
密度：1.41g/cm3
折射率：1.643
简介：Cilengitide(EMD121974)isamoleculedesignedandsynthesizedattheTechnicalUniversityMunichincollaborationwithMerckKGaAinDarmstadt.Itisbasedonthecyclicpeptidecyclo(-RGDfV-),whichisselectiveforαvintegrins,whichareimportantinangiogenesis(formingnewbloodvessels),andotheraspectsoftumorbiology.Hence,itisunderinvestigationforthetreatmentofglioblastoma,whereitmayactbyinhibitingangiogenesis,andinfluencingtumorinvasionandproliferation.
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